| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 11% | $154,666,182 | 11,379,207 | FMR LLC | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 8.2% | -6.7% | $121,662,640 | +$14,650,251 | 8,952,365 | +14% | Perceptive Advisors LLC | 30 Sep 2025 |
| BlackRock, Inc. | 7.1% | +32% | $94,028,025 | +$34,623,629 | 7,783,648 | +58% | BlackRock, Inc. | 31 Dec 2025 |
| Adage Capital Management, L.P. | 6.4% | -35% | $92,640,693 | -$26,951,307 | 6,816,828 | -23% | Adage Capital Management, L.P. | 30 Sep 2025 |
| Commodore Capital LP | 5.1% | $89,213,500 | 5,650,000 | Commodore Capital LP | 10 Nov 2025 | |||
| VANGUARD GROUP INC | 4.9% | -2% | $71,672,372 | +$10,542,372 | 5,273,750 | +17% | The Vanguard Group | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 2.6% | -54% | $38,074,233 | -$26,039,432 | 2,801,636 | -41% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Panacea Innovation Ltd | 2.6% | $7,678,000 | 2,200,000 | Panacea Venture Healthcare Fund II, L.P. | 31 Dec 2024 |
As of 30 Sep 2025, 168 institutional investors reported holding 109,720,694 shares of Amylyx Pharmaceuticals, Inc. - Common Stock (AMLX). This represents 100% of the company’s total 109,628,845 outstanding shares.
The largest institutional shareholders of Amylyx Pharmaceuticals, Inc. - Common Stock (AMLX) together control 80% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 10% | 11,379,207 | +273% | 0.01% | $154,643,424 |
| PERCEPTIVE ADVISORS LLC | 8.2% | 8,952,365 | +13% | 3.6% | $121,662,640 |
| BlackRock, Inc. | 6.5% | 7,140,692 | +30% | 0% | $97,042,005 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.2% | 6,816,828 | -23% | 0.15% | $92,640,693 |
| TCG Crossover Management, LLC | 5.7% | 6,243,812 | +5% | 4.2% | $84,853,405 |
| VANGUARD GROUP INC | 4.8% | 5,273,750 | +17% | 0% | $71,670,263 |
| Saturn V Capital Management LP | 4.2% | 4,604,878 | +41% | 14% | $62,580,292 |
| Commodore Capital LP | 3.7% | 4,075,478 | 2.7% | $55,385,746 | |
| First Light Asset Management, LLC | 3.1% | 3,355,882 | 4.3% | $45,606,436 | |
| Point72 Asset Management, L.P. | 2.5% | 2,790,066 | -38% | 0.08% | $37,916,998 |
| JANUS HENDERSON GROUP PLC | 2.3% | 2,536,233 | 0.02% | $34,454,725 | |
| Driehaus Capital Management LLC | 2.2% | 2,420,767 | +91% | 0.24% | $32,898,224 |
| Almitas Capital LLC | 1.9% | 2,122,597 | 0% | 6.6% | $28,846,093 |
| GOLDMAN SACHS GROUP INC | 1.8% | 2,010,633 | +55% | 0% | $27,324,503 |
| MORGAN STANLEY | 1.8% | 1,950,301 | +301% | 0% | $26,504,591 |
| Paradigm Biocapital Advisors LP | 1.7% | 1,900,000 | 0.76% | $25,821,000 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 1,812,039 | +7.1% | 0% | $24,631,001 |
| 683 Capital Management, LLC | 1.6% | 1,760,000 | -19% | 2.2% | $23,918,400 |
| GREAT POINT PARTNERS LLC | 1.6% | 1,700,000 | -15% | 9.6% | $23,103,000 |
| STATE STREET CORP | 1.5% | 1,621,260 | +61% | 0% | $22,032,923 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.4% | 1,512,500 | 0.34% | $20,554,948 | |
| Balyasny Asset Management L.P. | 1.3% | 1,476,302 | 0.04% | $20,062,944 | |
| Logos Global Management LP | 1.3% | 1,450,000 | 1.9% | $19,705,500 | |
| UBS Group AG | 1.3% | 1,404,471 | +12% | 0% | $19,086,761 |
| DEUTSCHE BANK AG\ | 1.2% | 1,365,521 | +121% | 0.01% | $18,557,430 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 65,029 | $785,731 | -$524,304 | $12.08 | 9 |
| 2025 Q3 | 109,720,694 | $1,491,122,082 | +$396,029,824 | $13.59 | 168 |
| 2025 Q2 | 81,690,006 | $523,632,250 | +$57,316,518 | $6.41 | 131 |
| 2025 Q1 | 73,877,500 | $261,528,744 | +$85,099,356 | $3.54 | 134 |
| 2024 Q4 | 49,783,588 | $188,178,786 | +$19,456,848 | $3.78 | 120 |
| 2024 Q3 | 43,406,257 | $140,608,833 | +$5,128,346 | $3.24 | 109 |
| 2024 Q2 | 43,634,536 | $82,910,614 | -$16,890,632 | $1.90 | 119 |
| 2024 Q1 | 49,483,582 | $140,533,695 | -$232,734,295 | $2.84 | 145 |
| 2023 Q4 | 33,518 | $493,385 | -$16,708,819 | $14.72 | 2 |
| 2023 Q3 | 58,927,724 | $1,078,967,056 | +$85,370,484 | $18.31 | 168 |
| 2023 Q2 | 54,460,975 | $1,174,838,680 | +$53,634,951 | $21.57 | 152 |
| 2023 Q1 | 51,372,917 | $1,507,230,828 | +$73,671,336 | $29.34 | 145 |
| 2022 Q4 | 48,530,384 | $1,793,199,591 | +$430,308,805 | $36.95 | 130 |
| 2022 Q3 | 36,575,728 | $1,029,606,460 | +$308,429,683 | $28.15 | 88 |
| 2022 Q2 | 26,620,916 | $512,892,346 | +$61,856,096 | $19.26 | 73 |
| 2022 Q1 | 23,330,516 | $298,773,403 | +$298,732,199 | $12.85 | 70 |