| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 10.7% | $155M | 11.4M | FMR LLC | Sep 30, 2025 | |||
| PERCEPTIVE ADVISORS LLC | 8.2% | -6.67% | $122M | $14.7M | 8.95M | +13.7% | Perceptive Advisors LLC | Sep 30, 2025 |
| Adage Capital Management, L.P. | 6.39% | -34.8% | $92.6M | -$27M | 6.82M | -22.5% | Adage Capital Management, L.P. | Sep 30, 2025 |
| Commodore Capital LP | 5.1% | $89.2M | 5.65M | Commodore Capital LP | Nov 10, 2025 | |||
| VANGUARD GROUP INC | 4.94% | -2% | $71.7M | $10.5M | 5.27M | +17.2% | The Vanguard Group | Sep 30, 2025 |
| BlackRock, Inc. | 5.5% | $25.3M | 4.92M | BlackRock, Inc. | Jun 30, 2025 | |||
| Point72 Asset Management, L.P. | 2.6% | -54% | $38.1M | -$26M | 2.8M | -40.6% | Point72 Asset Management, L.P. | Sep 30, 2025 |
| Panacea Innovation Ltd | 2.6% | $7.68M | 2.2M | Panacea Venture Healthcare Fund II, L.P. | Dec 31, 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 110M | $1.49B | +$396M | $13.59 | 167 |
| 2025 Q2 | 81.7M | $524M | +$57.3M | $6.41 | 130 |
| 2025 Q1 | 73.9M | $262M | +$85.1M | $3.54 | 134 |
| 2024 Q4 | 49.8M | $188M | +$19.5M | $3.78 | 120 |
| 2024 Q3 | 43.4M | $141M | +$5.13M | $3.24 | 109 |
| 2024 Q2 | 43.6M | $82.9M | -$16.9M | $1.90 | 119 |
| 2024 Q1 | 49.5M | $141M | -$233M | $2.84 | 145 |
| 2023 Q4 | 33.5K | $493K | -$16.7M | $14.72 | 2 |
| 2023 Q3 | 58.9M | $1.08B | +$85.4M | $18.31 | 168 |
| 2023 Q2 | 54.5M | $1.17B | +$53.6M | $21.57 | 152 |
| 2023 Q1 | 51.4M | $1.51B | +$73.7M | $29.34 | 145 |
| 2022 Q4 | 48.5M | $1.79B | +$430M | $36.95 | 130 |
| 2022 Q3 | 36.6M | $1.03B | +$308M | $28.15 | 88 |
| 2022 Q2 | 26.6M | $513M | +$61.9M | $19.26 | 73 |
| 2022 Q1 | 23.3M | $299M | +$299M | $12.85 | 70 |