Q2 2025 13F Holders as of 6/30/2025
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Type / Class
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Equity / Common Stock, par value $0.001 per share
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Shares outstanding
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54.3M
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Number of holders
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82
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Total 13F shares, excl. options
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48.4M
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Shares change
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+2.88M
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Total reported value, excl. options
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$531M
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Value change
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+$32.7M
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Number of buys
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53
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Number of sells
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-22
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Price
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$10.98
Significant Holders of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) as of Q2 2025
91 filings reported holding UPB - Upstream Bio, Inc. - Common Stock, par value $0.001 per share as of Q2 2025.
Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) has 82 institutional shareholders that have filed 13F forms with the Securities Exchange Commission (SEC).
These institutions hold a total of 48.4M shares
of 54.3M outstanding shares and own 89.07% of the company stock.
Largest 10 shareholders include FMR LLC (7.94M shares), ORBIMED ADVISORS LLC (5.69M shares), Altshuler Shaham Ltd (3.39M shares), Decheng Capital LLC (3.29M shares), TCG Crossover Management, LLC (2.8M shares), ENAVATE SCIENCES GP, LLC (2.46M shares), Bain Capital Life Sciences Investors, LLC (2.44M shares), VR ADVISER, LLC (2.3M shares), VANGUARD GROUP INC (2.17M shares), and BlackRock, Inc. (2.1M shares).
This table shows the top 82 institutional shareholders of the company equity. This data is sourced directly from the SEC via 13F filings.
| Investor |
Option |
Weight % |
Change % |
Value $ |
* Price $ |
Shares |
Share Change |
Activity |
Report Period |
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.