Q3 2025 13F Holders as of 9/30/2025
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Type / Class
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Equity / Common Stock, par value $0.001 per share
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Shares outstanding
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54.3M
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Number of holders
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92
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Total 13F shares, excl. options
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44.5M
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Shares change
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-3.9M
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Total reported value, excl. options
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$836M
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Value change
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-$50.8M
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Put/Call ratio
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0.05
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Number of buys
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57
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Number of sells
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-32
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Price
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$18.81
Significant Holders of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) as of Q3 2025
109 filings reported holding UPB - Upstream Bio, Inc. - Common Stock, par value $0.001 per share as of Q3 2025.
Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) has 92 institutional shareholders that have filed 13F forms with the Securities Exchange Commission (SEC).
These institutions hold a total of 44.5M shares
of 54.3M outstanding shares and own 81.9% of the company stock.
Largest 10 shareholders include FMR LLC (8.09M shares), ORBIMED ADVISORS LLC (5.69M shares), Decheng Capital LLC (3.29M shares), BlackRock, Inc. (2.6M shares), ENAVATE SCIENCES GP, LLC (2.46M shares), VANGUARD GROUP INC (2.44M shares), Bain Capital Life Sciences Investors, LLC (2.44M shares), TCG Crossover Management, LLC (2.12M shares), Altshuler Shaham Ltd (1.42M shares), and Omega Fund Management, LLC (1.36M shares).
This table shows the top 92 institutional shareholders of the company equity. This data is sourced directly from the SEC via 13F filings.
| Investor |
Option |
Weight % |
Change % |
Value $ |
* Price $ |
Shares |
Share Change |
Activity |
Report Period |
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.