| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 14% | 22,735,121 | 0 | 22,735,121 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 13% | 20,126,582 | 0 | 20,126,582 | Kristin Mariani | Head of North America Compliance, CCO |