| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 11% | 17,688,592 | 0 | 17,688,592 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 9.6% | 15,203,597 | 0 | 15,203,597 | Kristin Mariani | Head of North America Compliance, CCO |