Fmr Llc

13F Holdings History for Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Symbol: UPB on Nasdaq
Investment type: Equity / Common Stock, par value $0.001 per share
Latest Disclosed Ownership: 7.94M shares
Security Ownership: 14.8%

Shares, Excluding Options vs Price

Value, Excluding Options

FMR LLC ownership in Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB)

2025-08-06 - FMR LLC has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 7.94M shares of Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB). This represents 14.8% percent ownership of the company. In their previous filing dated 2025-02-12, FMR LLC had reported owning 7.18M shares, indicating an increase of 10.6% percent.

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filed at
FMR LLC	14.8%	+10.8%	$75.4M	7.94M	+760,693	+10.6%	$9.50	13G/A	6/30/2025	6 Aug 2025 12:19:41
FMR LLC	13.4%		$52.9M	7.18M			$7.37	13G/A	12/31/2024	12 Feb 2025 09:34:21

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
9/30/2025	0.01%	+0%	$152M	8.09M	+149,533	+1.88%	$18.81	Q3 2025
6/30/2025	0%	+0%	$87.1M	7.94M	+681,021	+9.39%	$10.98	Q2 2025
3/31/2025	0%	+0%	$44.4M	7.26M	+79,672		$6.12	Q1 2025
12/31/2024	0.01%	+0.01%	$118M	7.18M	+7,176,187	NEW	$16.44	Q4 2024

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.