FMR LLC

Holdings History for Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Symbol: UPB on Nasdaq
Investment type: Equity / Common Stock, par value $0.001 per share
Latest Disclosed Shares Owned: 7,936,880 shares
Security Ownership %: 15%

Shares, Excluding Options vs Price

Value, Excluding Options

FMR LLC ownership in Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB)

06 Aug 2025 - FMR LLC has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 7,936,880 shares of Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB). This represents 15% ownership of the company. In their previous filing dated 12 Feb 2025, FMR LLC had reported owning 7,176,187 shares, indicating an increase of +11%. .

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filing time
FMR LLC	15%	+11%	$75,400,363	7,936,880	+760,693	+11%	$9.50	13G/A	30 Jun 2025	06 Aug 2025, 12:19
FMR LLC	13%		$52,888,498	7,176,187			$7.37	13G/A	31 Dec 2024	12 Feb 2025, 09:34

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
30 Sep 2025	0.01%	+0%	$152,105,434	8,086,413	+149,533	+1.9%	$18.81	Q3 2025
30 Jun 2025	0%	+0%	$87,146,946	7,936,880	+681,021	+9.4%	$10.98	Q2 2025
31 Mar 2025	0%	+0%	$44,405,857	7,255,859	+79,672		$6.12	Q1 2025
31 Dec 2024	0.01%	+0.01%	$117,976,514	7,176,187	+7,176,187	NEW	$16.44	Q4 2024

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.